chris wright cyclerion
SCD is an inherited red blood cell disorder that causes red blood cells to deform into a sickle shape, impacting blood flow to organs and tissues. We are excited about the therapeutic possibilities for IW-6463 as a first-in-class, brain penetrant sGC stimulator," said Chris Wright, M.D., Chief Medical Officer of Cyclerion. Nitric oxide is one of several fundamental neurotransmitters, but it has yet to be leveraged for its full CNS therapeutic potential. We also use third-party cookies that help us analyze and understand how you use this website. In preclinical studies, IW-6463 has been associated with increased cerebral blood flow, reduced markers of neuroinflammation, enhanced cognition, neuroprotection and enhanced cellular bioenergetics.Cyclerion Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of sGC pharmacology to discover, develop and commercialize breakthrough treatments for serious and orphan diseases. Upon red blood cell rupturing, nitric oxide is depleted due to arginase release and hemoglobin scavenging. sGC is expressed widely throughout the CNS and CNS vasculature.CAMBRIDGE, Mass., April 10, 2020 (GLOBE NEWSWIRE) -- Cyclerion Therapeutics, Inc. (NASDAQ:CAMBRIDGE, Mass., April 10, 2020 (GLOBE NEWSWIRE) -- Cyclerion Therapeutics, Inc. (NASDAQ:"We are looking forward to a catalyst-rich period in the coming months with top line results from both our translational pharmacology study for IW-6463, our brain-penetrant sGC stimulator designed to treat neurodegenerative diseases, and our olinciguat Phase 2 study for sickle cell disease.
There are clear links between nitric oxide signaling defects and neurodegenerative diseases. Topline study data are expected in late summer 2020.This webcast event will focus on IW-6463, the company's investigational, orally administered, once-daily CNS-penetrant sGC stimulator designed for the treatment of serious CNS diseases. If you have any questions feel free to call us at 1-877-440-ZING or email us at Get pre-market outlook, mid-day update and after-market roundup emails in your inbox.Everything you need to know about the market - quick & easy.A daily collection of all things fintech, interesting developments and market updates. Applicable risks and uncertainties include those related to our ability to obtain necessary approvals from regulatory authorities; our ability to advance product candidates in clinical trials; that regulatory approval processes are lengthy, time-consuming and inherently unpredictable; that significant variability in safety or efficacy may appear in different clinical studies of the same product candidate; that product candidates in later stages of clinical studies often fail to demonstrate adequate safety and efficacy despite promising preclinical testing and earlier clinical studies; the timing, investment and associated activities involved in developing and obtaining regulatory approval for our product candidates; our plans with respect to the development of our product candidates and the associated timing thereof, including the design and results of pre-clinical and clinical studies; the efficacy of our product candidates; and the risks more fully listed under the heading "Risk Factors" and elsewhere in our Registration Statement on Form 10 filed on March 11, 2019, and in Cyclerion's subsequent SEC filings, including the Form 10-Q filed on November 12, 2019. We also use third-party cookies that help us analyze and understand how you use this website. The Company is tightly managing its spending. We are excited about the therapeutic possibilities for IW-6463 as a first-in-class, brain penetrant sGC stimulator," said Chris Wright, M.D., Chief Medical Officer of Cyclerion. Mendelsohn brings over 30 years of experience as an academic and industry leader in R&D, as well as expertise as a cardiovascular clinician and scientist and as a consultant to leading research efforts for multinational biopharmaceutical companies. We look forward to the top line results in Q3 2020 and to making a data-driven decision regarding advancement to the next phases of development," said Chris Wright, M.D., Cyclerion… sGC stimulators work synergistically with the nitric oxide naturally produced in the body to boost the positive effects of nitric oxide, even when the body is not producing enough. You also have the option to opt-out of these cookies. McGuire brings 25 years of biotechnology venture capital experience as co-founder and general partner of Polaris Partners, including early stage investing in over 50 medical and information technology companies.
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